PT - 141

PT-141 (Bremelanotide) is a synthetic cyclic peptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH) studied for its central effects on the melanocortin system and sexual behavior. Unlike PDE5 inhibitors which act peripherally on vascular smooth muscle, PT-141 research focuses on direct central nervous system pathways affecting sexual motivation and arousal in preclinical models.

Mechanism of Action

•        Activates melanocortin receptors (MC1R, MC3R, MC4R) in the hypothalamus and limbic system, studied for effects on sexual arousal pathways in animal models.

•        Investigated for increases in dopaminergic activity in the mesolimbic system, influencing motivation-related neurobiology.

•        Research suggests stimulation of nitric oxide synthesis in relevant neural circuits.

•        Studies indicate activity regardless of vascular health status, distinguishing its mechanism from PDE5-based pharmacology.

Research Areas

•        Hypoactive sexual desire disorder (HSDD) research; an FDA-approved indication exists for a subcutaneous formulation.

•        Erectile dysfunction biology, including cases studied alongside or in comparison to PDE5 inhibitor mechanisms.

•        Sexual dysfunction secondary to pharmacological interventions.

•        Central arousal pathway and melanocortin system research.

Presentation and Storage

Supplied as a lyophilized powder in a sealed vial containing 10mg of PT-141. Reconstitute with bacteriostatic water for laboratory use. Store at -20C.