AHK- CU

AHK-Cu (Ala-His-Lys copper complex) is a synthetic tripeptide that forms a stable complex with copper ions. Structurally distinct from GHK-Cu, it has been studied primarily in the context of topical and external applications, with research focusing on its influence on skin biology, collagen synthesis, and dermal remodeling. Its copper-chelating properties make it of interest in cosmetic science and wound biology when applied externally to tissue.

Mechanism of Action

•        Investigated for its ability to deliver bioavailable copper to skin tissue, supporting copper-dependent enzyme activity including lysyl oxidase, which is essential for collagen and elastin cross-linking.

•        Research suggests stimulation of fibroblast activity and extracellular matrix component synthesis when applied topically in cell models.

•        Studied for antioxidant properties at the dermal level through copper-mediated superoxide dismutase (SOD) pathway activation.

•        Preclinical studies indicate potential modulation of skin cell proliferation and migration relevant to wound healing models.

•        Investigated for reduction of matrix metalloproteinase (MMP) activity associated with collagen degradation in aging skin biology.

Research Areas

•        Topical skin aging and dermal remodeling research.

•        Collagen and elastin synthesis studies in fibroblast cell models.

•        Wound healing biology in external tissue application models.

•        Hair follicle and scalp biology in topical application research.

•        Copper-dependent enzyme activity research in dermal systems.

Presentation and Storage

Supplied as a lyophilized powder in a sealed vial containing 50mg of AHK-Cu. Intended for topical and external research applications only. Reconstitute with appropriate carrier solution for external use. Store at -20C.