KPV

KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (alpha-MSH). It has been studied for its anti-inflammatory and immunomodulatory properties without the melanotropic activity of the parent molecule. Research has focused on its potential role in gut biology, skin inflammation, and systemic immune regulation.

Mechanism of Action

•        Research shows inhibition of NF-kB signaling, a key regulator of the inflammatory response, reducing pro-inflammatory cytokine production in cell models.

•        Studies suggest the ability to penetrate cellular and nuclear membranes, influencing inflammatory transcription directly.

•        Investigated for its role in supporting intestinal epithelial barrier integrity by reducing tight junction permeability.

•        Studied for interaction with melanocortin receptors (MCR1 and MCR3) in innate immune modulation research.

Research Areas

•        Intestinal permeability and inflammatory bowel biology research.

•        Skin inflammation models including eczema, psoriasis, and wound biology.

•        Systemic inflammatory and autoimmune-related tissue damage studies.

•        Joint inflammation and local inflammatory marker research.

Presentation and Storage

Supplied as a lyophilized powder in a sealed vial containing 10mg of KPV. Reconstitute with bacteriostatic water for laboratory use. Store at -20C.