SLU- PP- 32

SLU-PP-332 is a small-molecule agonist of estrogen-related receptors (ERRa and ERRy), nuclear receptors that regulate mitochondrial biogenesis, fatty acid oxidation, and energy expenditure. Research has demonstrated that SLU-PP-332 can activate molecular adaptations associated with aerobic exercise, making it of significant interest in metabolism and longevity research.

Mechanism of Action

•        Activates ERRa and ERRy, upregulating genes involved in oxidative phosphorylation, fatty acid beta-oxidation, and mitochondrial biogenesis in preclinical models.

•        Increases expression of PGC-1a co-activators, promoting mitochondrial density in skeletal and cardiac muscle tissue.

•        Studies show stimulation of fast-to-slow fiber type switching in skeletal muscle, improving oxidative capacity.

•        Investigated for enhancement of fatty acid utilization as an energy substrate in metabolic research.

Research Areas

•        Metabolic disease research including obesity, insulin resistance, and type 2 diabetes models.

•        Exercise mimetic biology in sarcopenia and mitochondrial decline studies.

•        Cardiac and skeletal muscle bioenergetics research.

•        Longevity research targeting mitochondrial function and metabolic efficiency.

Presentation and Storage

Supplied as a lyophilized powder in a sealed vial containing 10mg of SLU-PP-332. Reconstitute with appropriate solvent for laboratory use. Store at -20C.