TB - 500

TB-500 is a synthetic peptide derived from Thymosin Beta-4 (Tb4), a naturally occurring protein abundantly expressed in platelets and wound fluids. It has been studied extensively for its tissue repair properties, acting through actin regulation to promote cell migration, angiogenesis, and healing across multiple tissue types in preclinical research.

Mechanism of Action

•        Binds to actin monomers (G-actin), studied for its role in cytoskeletal dynamics essential for cell migration and wound repair.

•        Research indicates stimulation of endothelial cell migration and capillary formation (angiogenesis).

•        Investigated for upregulation of metalloproteinases and matrix remodeling in tissue repair models.

•        Preclinical studies show anti-inflammatory effects through reduction of NF-kB signaling and macrophage activity modulation.

•        Studied for promotion of stem cell differentiation and migration to sites of injury in animal models.

Research Areas

•        Tendon, ligament, and muscle repair in acute and chronic injury research models.

•        Cardiovascular tissue regeneration research in cardiac ischemia models.

•        Neural repair and neurological recovery studies post-injury.

•        Fibrosis reduction research in chronically damaged tissue.

•        General tissue healing and regeneration biology.

Presentation and Storage

Supplied as a lyophilized powder in a sealed vial containing 10mg of TB-500. Reconstitute with bacteriostatic water for laboratory use. Store at -20C.