CJC - 1295

CJC-1295 without DAC (also known as Mod GRF 1-29) is a truncated analog of growth hormone-releasing hormone (GHRH) studied for its ability to stimulate pituitary GH release in a physiologically pulsatile manner. Without the drug affinity complex, it maintains a shorter half-life that more closely mirrors natural GH secretion patterns in research models, reducing the risk of receptor desensitization.

Mechanism of Action

•        Binds to GHRH receptors on somatotropic cells of the anterior pituitary, studied for stimulation of GH synthesis and pulsatile secretion.

•        Downstream GH release elevates IGF-1 levels in animal research, mediating anabolic, regenerative, and lipolytic effects.

•        Preserves natural GH pulsatility in studies, reducing the risk of receptor desensitization compared to longer-acting analogs.

•        Investigated for synergy with GHRPs such as Ipamorelin through complementary receptor pathway activation.

Research Areas

•        Growth hormone biology and somatotropic axis research.

•        Body composition research including fat metabolism and lean mass studies.

•        Sleep quality and nocturnal GH secretion biology.

•        Skin and cellular repair research through IGF-1 pathway analysis.

•        Metabolic health and energy homeostasis studies.

Presentation and Storage

Supplied as a lyophilized powder in a sealed vial containing 10mg of CJC-1295 no DAC. Reconstitute with bacteriostatic water for laboratory use. Store at -20C.